CIALIS generico usually refers to a generic drug of sildenafil (Cialis).
Guía de Salud Masculina
1. Mechanism of Drug Action
1、action principle
- Sildenafil belongs to a phosphodiesterase type 5 (PDE5) inhibitor. During the pathophysiological process of male erectile dysfunction (ED), sexual stimulation promotes the release of nitric oxide (NO) from the nerve terminals of the corpus cavernosum of the penis. NO activates guanylate cyclase and increases the synthesis of cyclic guanosine monophosphate (cGMP). cGMP can cause relaxation of the smooth muscle of the corpus cavernosum of the penis, and blood flows into the corpus cavernosum, leading to erection.
- PDE5 degrades cGMP, causing erection to fail to be maintained. Sildenafil inhibits PDE5 and reduces the degradation of cGMP, thereby enhancing erectile function.
2. Information related to generic drugs
1、definition and characteristics
- Generic drugs are drugs that are the same as the original drug in terms of active ingredients, dosage form, route of administration and therapeutic effects.
- Its advantage is that it has lower costs and can provide affordable treatment options for more patients. While ensuring that the quality and efficacy are comparable to those of the original drug, generic drugs can improve the accessibility of drugs.
2、quality Supervision
- In different countries, the production and sales of generic drugs are strictly regulated. In the European Union, generic drugs must be approved by the European Medicines Agency (EMA) to prove that they are bioequivalent to the original drug, that is, the speed and degree of absorption of the drug in the body are similar.
- In the United States, the Food and Drug Administration (FDA) also has strict regulations to ensure the quality, safety and effectiveness of generic drugs.
3. Precautions for use
1、Applicable population and contraindications
- Sildenafil is mainly indicated for male patients with erectile dysfunction, but is contraindicated for patients taking nitrates such as nitroglycerin because their combination may cause severe hypotension.
- Patients with cardiovascular disease should consult a doctor before using it, because sexual activity itself has certain requirements on the cardiovascular system, and sildenafil may affect physiological parameters such as blood pressure.
2、adverse reactions
- Common adverse reactions include headache, facial flushing, indigestion, nasal congestion, dizziness, etc. These adverse reactions are usually mild to moderate and gradually reduce or disappear after drug metabolism.